Search on: ANTIDEPRESSIVE AGENTS 
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Descriptor English:   Antidepressive Agents 
Descriptor Spanish:   Antidepresivos 
Descriptor Portuguese:   Antidepressivos 
Synonyms English:   Thymoanaleptics
Thymoleptics
Antidepressants  
Tree Number:   D27.505.954.427.700.122
Definition English:   Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. 
Indexing Annotation English:   GEN or unspecified; prefer specific groups or specific antidepressive agents; consider also DEPRESSION /drug ther
See Related English:   Monoamine Oxidase Inhibitors
 
History Note English:   66; PSYCHIC ENERGIZERS was see ANTIDEPRESSIVE AGENTS 1963-94; THYMOLEPTICS was see TRANQUILIZING AGENTS 1969-78 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DU diagnostic use
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   935 
Unique Identifier:   D000928 

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